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Loren Pickart
The most frequently reported adverse effects are gastrointestinal: nausea, vomiting, and diarrhea, which in published RCTs often occurred at rates similar to or only modestly above placebo
Specifically, histone Kla, especially H3K18la, enhances the transcriptional activity of NFS1 cysteine desulfurase (NFS1), a key player in ironsulfur cluster biosynthesis, thereby reducing the susceptibility of HCC to ferroptosis and promoting metastasis
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